PME-1 AS A BIOMARKER TO PREDICT AND DIAGNOSE ENDOMETRIAL AND BREAST CANCER AND GENE SILENCING OF PME-1 TO INHIBIT EPITHELIAL TO MESENCHYMAL TRANSITION

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专利权人:

Lyndi M. Rice

发明人:

Lyndi M. Rice,Michelle Pusey

申请号：

US14514859

公开号：

US20150284723A1

申请日:

2014.10.15

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Disclosed are methods of attenuating activity of the PME-1 gene. siRNAs or shRNAs are used to target against PME-1, thereby reducing the PME-1 mRNA. It is disclosed that the siRNAs or shRNAs targeted against PME-1 attenuate the epithelial to mesenchymal transition, thereby inhibit endometrial cancer and triple negative breast cancer development. A kit containing siRNA or shRNA reagents for attenuating the PME-1 gene expression is also disclosed.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/