THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人:
GEORGIOU, GEORGE,STONE, EVERETT
申请号：
CA2788689
公开号：
CA2788689C
申请日:
2011.02.03
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Methods and composition related to the engineering of a novel protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
