The present invention discloses a transdermal sensor. The transdermal sensor includes a substrate, an electrochemical sensor unit, a signal processing unit and a power supply unit. Therein, the electrochemical sensor unit is composed of array micro needle. The transdermal sensor pierces skin by micro needle with minimally invasive. The micro needle can reduce the pain of user and achieve the goal of detecting the concentration of hypodermic target molecules to get the physiological signal of body.本創作係為一種經皮感測器,其包括:基板;電化學感測單元;訊號處理單元;以及電源單元。其中,電化學感測單元是由陣列排列的微針所組成,而經皮感測器係藉由微針低侵入性穿刺皮膚,減輕使用者的疼痛感,且可達到量測皮下目標分子濃度,以獲知人體生理訊號的目的。