The present application provides a reusable powered endoscopic cutter stapler, comprising a controller, a handle, an adapter and a cable component; the adapter is connected with the handle; one end of the cable component is detachably connected with the controller, the other end is detachably connected with the handle to be used for transmitting electric energy and command signals; the controller can be reused for many times, and the cable component can be reused for many times after being sterilized. According to the reusable powered endoscopic cutter stapler disclosed by the present application, at least one or multiple components of a core component can be sterilized repeatedly, and can be used for many times, thereby not only greatly lowering the treatment expense of patients, but also greatly reducing the risk of cross infection when instruments are used, improving the use safety and reliability of the instruments, and greatly lightening the overall mass, so that a doctor can operate more conveniently.