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Novel benzimidazole derivatives as kinase inhibitors
专利权人:
SELVITA S.A.
发明人:
CZARDYBON, Wojciech,BRZOZKA, Krzysztof,GALEZOWSKI, Michal,WINDAK, Renata,MILIK, Mariusz,ZAWADZKA, Magdalena,GUZIK, Pawel,WINCZA, Ewelina,PROKOP, Marta,WIKLIK, Katarzyna,SABINIARZ, Aleksandra,CHOLODY,
申请号:
ES13811246
公开号:
ES2688395T3
申请日:
2013.12.20
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Compound of formula (I): ** Formula ** in which X1 is selected from the group consisting of nitro, cyano, trifluoromethyl and -C (>; = O) OT4; Z and X2 are each independently selected from the group consisting of F, Cl, Br and I; X3 is isopropyl or ethyl; X4 is either absent or is selected from -NR4- and -N (R4) (CH2) -; R4 is selected from H and -C 1-6 alkyl; Y1 is selected from the group consisting of H, -C1-6 alkyl and a saturated or unsaturated aromatic carbocycle or heterocycle of 4 to 7 members, with the proviso that the point of attachment in said heterocycle is carbon if X4 is - NR4- or -N (R4) (CH2) -, wherein said -C1-6 alkyl is optionally substituted with one or more substituents independently selected from F, - OT1, -N (T2) (T3), -C ( >; = O) N (T2) (T3), -C (>; = O) OT1, -ST1, -S (>; = O) 2T1, -S (>; = O) 2N (T2) (T3) and a heterocycle saturated from 5 to 6 members, and wherein said 4 to 7 member carbocycle or heterocycle is optionally substituted with one or more substituents independently selected from F, - OT1, -N (T2) (T3), -C (>; = O) N (T2) (T3), -C (>; = O) OT1, -ST1, -S (>; = O) 2T1, -S (>; = O) 2N (T2) (T3), oxo and -alkyl C1-3, wherein said C1-3alkyl is optionally substituted with one or more substituents independently selected from -OT7, -N (T2) (T3) and a 6-membered saturated heterocycle; T1, T2 and T3 are each independently selected from H and -C 1-6 alkyl optionally substituted with one or more substituents independently selected from F, -N (T5) (T6), -OT7, -ST7, cyano, -C ( >; = O) OT7, -C (>; = O) N (T5) (T6), -OC (>; = O) N (T5) (T6), -S (>; = O) 2T7, -S (>; = O) 2OT8 and - S (>; = O) 2N (T5) (T6); T4 is -C 1-6 alkyl optionally substituted with one or more substituents independently selected from F, -N (T5) (T6), -OT7, -ST7, cyano, -C (>; = O) OT7, -C (>; = O) N (T5) (T6), - OC (>; = O) N (T5) (T6), -S (>; = O) 2T8, -S (>; = O) 2OT7 and -S (>; = O) 2N (T5) (T6); T5, T6 and T7 are each independen
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