一種鈉依賴性葡萄糖共轉運蛋白抑制劑的胺溶劑合物及其製備方法和應用

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专利权人:

YOUNGENE THERAPEUTICS CO., LTD;上海研健新藥研發有限公司

发明人:

ZHANG, Lei,WANG, Yuan,WANG, Yuan,王元

申请号：

HK18113918

公开号：

HK1254827A1

申请日:

2018.10.31

申请国别(地区):

HK

年份:

2019

代理人:

摘要：

Disclosed are an amine solvate of a sodium-glucose linked transporter (SGLT) inhibitor, and a preparation method and application thereof. The SGLT inhibitor is (1 S ,2 S ,3 S ,4 R ,5 S )-5-(3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-4-ethylbenzyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol. Further provided is a crystalline compound of the amine solvate, a pharmaceutical composition comprising the amine solvate, and an application of the amine solvate in preparing an SGLT-inhibiting pharmaceutical product.

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