Produced enzyme containing methionine gamma lyase enzyme and pharmacological preparation thereof

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专利权人:

イーメーズ インコーポレイテッド

发明人:

ゲオルギオウ ジョージ,ストーン エバレット

申请号：

JP2012552084

公开号：

JP5875990B2

申请日:

2011.02.03

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

Methods and composition related to the engineering of a novel protein with methionine-γ-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/