Shawn Defrees,Robert J. Bayer,Caryn Bowe,Krishnasamy Panneerselvam
申请号：
US15005566
公开号：
US20160184412A1
申请日:
2016.01.25
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Conjugates between Factor IX and PEG moieties, are disclosed in the present application. The conjugates are linked via a glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. Conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
