A method of reducing an involuntary cull in production animals. The method comprising the step of administering to the production animals a composition comprising an effective amount of a pomegranate extract substantially derived from the whole fruits of pomegranate. The pomegranate extract can be in powder, liquid or solid form and mixed into foods as part of a regular regime of the production animals diet. When site specific treatment is needed such as with mastitis in milk cows the pomegranate extract may be injected directly to the site where treatment is desired.