Jeffrey N. Agar,Gregory A. Petsko,Dagmar Ringe,Walter R. P. Novak
申请号：
US12532309
公开号：
US08609649B2
申请日:
2008.03.20
申请国别(地区):
US
年份:
2013
代理人:
摘要：
One aspect of the invention relates to a method of treating or preventing a neurodegenerative disease, comprising the step of administering to a patient in need thereof a therapeutically effective amount of an inhibitor of the formation of advanced glycation end products. Another aspect of the invention relates to a proteasome activity-based screening assay to select compounds which may be useful for treating or preventing a neurodegenerative disease, and the materials used therein. Yet another aspect of the invention relates to molecules, and methods of use thereof, which bind at or adjacent to SOD-I Trp32, including molecules that bind in a site adjacent to SOD-I Trp32 whether or not it is oxidized, for treating or preventing neurodegenerative disease.
