A protective cap (1) for application to a medical device (2), such as a medical vial, comprising said protective cap (2) a membrane support (3) having a first end (4) with an end wall (6), said end wall (6) an outer surface (7) and an inner surface (8) and a second end (5) with an end opening (9) at a distance from said first end (4), adapted said second end (5) to be placed on a receiving portion of said medical device (2) and being provided with connection means (10) for connecting said protective cap (1) to said medical device (2), said end wall (6) of said support membrane (3) a borehole (15), said bore hole (15) a peripheral edge (16), wherein an elastic membrane (18) is disposed to cover said borehole (15), said membrane comprising Elastic ca (18) having a piercing portion (20) and a sealing portion (22), said piercing portion (20) of said elastic membrane (18) through said borehole (15), said support comprising membrane (3) fastening means (24) for fixing said elastic membrane (18) to said support membrane (3), said elastic membrane (18) being fixed to said support membrane (3) with said piercing portion ( 2) of said elastic membrane (18) exposed through said borehole (15) in said end wall (6) of said support membrane (3) and said sealing portion (22) of said elastic membrane (18 ) arranged to be brought into sealing contact with said receiving portion of said medical device (2) when said protective cap (1) is applied to said medical device (2), characterized in that said sealing portion (22) of said membrane (18) extends beyond said peripheral edge (16) of said bore hole (15) on said inner surface (8) of said end wall (6) of said support membrane (3) and that said fixing means (24) are means luting or mechanical fixing means or a combination of adhesive attachment means and mechanical fixing means.Una caperuza de protección (1) para aplicación sobre un dispositivo médico (2), tal como un vial médico, comprendiendo dicha caperuza de protección (2) un soporte