HADIDA-RUAH, SARA,MILLER, MARK,ZHOU, JINGLAN,BEAR, BRIAN,GROOTENHUIS, PETER
申请号：
ES12188920
公开号：
ES2552990T3
申请日:
2009.03.25
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: RN is H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl or heterocycloalkyl； A is a 3-membered monocyclic ring； B is optionally condensed to a 5-7 membered ring selected from the group consisting of cycloaliphatic, aryl, heterocyclic and heteroaryl； R1 is halo, alkyl, OH, alkoxy, thioalkyl, trifluoromethoxy； or two R1 in adjacent atoms that, taken together, form: ** Formula ** in which J is selected from the group consisting of CH2, CF2 or C (CH3) 2； W is, independently, an optionally substituted (C1-C6) alkylidene bond or chain, in which up to two methylene units of W are independently replaced by -O-, -S-, -SO2- or -NR'-； R 'is, independently, H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl or heterocycloalkyl； Rw is, independently, H, CN, NO2, N (R) 2, CF3, OCF3, OH, OR, C (O) N (R) 2, C (O) R, CO2R, -O (alkylidene ( C1-C6)) - OR, O (C1-C6 alkylidene) - N (R) 2, -O (C1-C6 alkylidene) - heterocycle or an aliphatic, cycloaliphatic, aryl, aryloxy, heterocyclic or heteroaryl, wherein, when substituted, Rw is substituted with up to two R2； R2 is halo, CN, NO2, CF3, OCF3, OR, OC (O) R, OC (O) N (R) 2, SR, S (O) R, SO2R, SO2N (R) 2, SO3R, C ( O) R, CO2R, C (O) N (R) 2, N (R) 2, NRC (O) R, NRCO2R, NRC (O) N (R) 2, NRSO2R, B (OH) 2 or NRSO2N ( R) 2； R is independently H, alkyl, cycloalkyl, heterocyclic, aryl or heteroaryl； n is 1 or 2； w is an integer from 0 to 4 inclusive； and x is an integer from 0 to 5 inclusive； provided that when W is a bond and Rw is cycloaliphatic, heterocycloaliphatic, aryl or heteroaryl, -W-Rw will be attached to position 3 or 4 of the pyridyl ring.Un compuesto de fórmula I:**Fórmula** o una sal farmacéuticamente aceptable del mismo, en el que: RN es H, alquilo, arilo, heteroarilo, aralquilo, cicloalquilo o heterocicloalquilo； A es un anillo monocíclico de 3 miembros； B está opcionalmente condensado a un anillo de 5-7 miembros seleccionado del grupo que c
