John Robert POLLARD,Peter LITTLEWOOD,Philip Michael REAPER,Mohammed ASMAL,Scott Zachary FIELDS
申请号：
US15763366
公开号：
US20180303829A1
申请日:
2016.09.30
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Described herein are methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a DNA damaging agent and between about 12 and about 48 hours later administering to the subject a compound that inhibits ATR protein kinase. Methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a compound that inhibits ATR protein kinase are also described. Exemplary ATR inhibitors are represented by Formulae A-I and A-II or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.
