吡啶并-嘧啶衍生物，其製備及其應用农业专利-农业学术服务平台

发明人:: BOURRIE, BERNARD,伯纳　鲍瑞,伯納　鮑瑞,CASELLAS, PIERRE,皮尔　卡瑟拉斯,皮爾　卡瑟拉斯,JEGHAM, SAMIR,萨米尔　杰格姆,薩米爾　傑格姆,PERREAUT, PIERRE,皮尔　帕瑞欧特,皮爾　帕瑞歐特,伯纳鲍瑞,伯納鮑瑞,皮尔卡瑟拉斯,皮爾卡瑟拉斯,萨米尔杰格姆,薩米爾傑格姆,皮尔帕瑞欧特,皮爾帕瑞歐特

摘要：: The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I): and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.本發明關於下式(I)之化合物：其中－R1代表(C1－C6)烷基或NR2R3或CH2COR4基；－R2及R3各獨立代表氫原子或(C1－C6)烷基；－R4代表羥基、(C1－C4)烷氧基、胺基、(C1－C4)烷基胺基或二(C1－C4)烷基胺基；－Ar1代表選自以下之基：－Ar2代表苯基，其可未經取代或以類似或不同之選自鹵素原子及(C1－C4)烷基、三氟甲基或(C1－C4)烷氧基之取代基取代1至5次。本發明亦揭示其製法及其治療上之應用。