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Novel EP4 agonist
专利权人:
Limited;Kaken Pharmaceutical Co., Ltd.;Asahi Glass Company, Limited;Asahi Glass Company
发明人:
Murata, Takahiko,Amakawa, Masahiro,Teradaira, Shin,Matsumura, Yasushi,Konishi, Katsuhiko
申请号:
AU2011225259
公开号:
AU2011225259A1
申请日:
2011.03.08
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
Disclosed are: a compound which has excellent metabolic stability and selectively binds to EP4 receptor; and a pharmaceutical product which contains the compound.Specifically disclosed is a compound represented by formula (1) (wherein R and R each independently represents a hydrogen atom or a linear alkyl group having 1-3 carbon atoms, and R represents a hydrogen atom, an alkyl group having 1-4 carbon atoms, an alkoxyalkyl group, an aryl group, a halogen atom or a halogenated alkyl group) or a pharmaceutically acceptable salt thereof, which is different from publicly known PGIs and has a selective EP4 agonist action. Consequently, a pharmaceutical product which contains the compound is useful for prophylaxis and/or treatment of immune diseases, cardiovascular diseases, heart diseases, respiratory diseases, eye diseases, kidney diseases, hepatic diseases, bone diseases, digestive tract diseases, neurological diseases, skin diseases and the like.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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