In detail, in the Bcl-2 family which induces apotoshisu, the peptide of specification of the C- region of Noxa which is the BH3-only member, discovering the fact that it has the activity which kills the cancer cell it developed this invention, in regard to new cell dead induction peptide, it regards new cell dead induction peptide and the cell dead induction fusion protein which includes this. According to this invention, because cell dead induction peptide, shows powerful cell extinction activity much in comparison with the cell dead derived protein of former TRAIL and the like, remedy of various cells which require extinction, especially, it is possible to use for the remedy of the cancer cell effectively.本発明は、新たな細胞死誘導ペプチドに関し、より詳細には、アポトーシスを誘発するBcl-2ファミリーの中、“BH3-only”メンバーであるNoxaのC-末端部位の特定のペプチドが、癌細胞を殺す活性を持つことを見出して開発した、新たな細胞死誘導ペプチドと、これを含む細胞死誘導融合蛋白質に関する。本発明によれば、細胞死誘導ペプチドが、従来のTRAILなどの細胞死誘導蛋白質に比べて、遥かに強力な細胞死滅活性を示すので、死滅を要する各種細胞の治療、特に、癌細胞の治療に効果的に用いることができる。
