MARTINBOROUGH, ESTHER,LEHSTEN, DANIELLE,NEUBERT, TIMOTHY,KAWATKAR, AARTI,ZIMMERMANN, NICOLE,TERMIN, ANDREAS
申请号：
ES06816908
公开号：
ES2383090T3
申请日:
2006.10.12
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula I: ** Formula ** or a pharmaceutically acceptable salt thereof； in which: the Z ring is, in which Z is optionally substituted with up to z occurrences of Rz； z is 0 to 4； each Rz independently selected from R1, R2, R3, R4 and R5； the SO2 group binds to any of the # 1 or 2 carbons； the NRM-C (O) -Q-RQ group binds to any of the # 3 carbons 'or 4'； in which the phenyl ring containing carbon # 3 'is optionally substituted with up to 4 substituents selected from halo, CN, NO2 CF3, OCF3, OR6, SR6, S (O) R2, SO2R2, NH2, N (R2) 2, COOR2 and a linear or branched C1-C6 alkylidino chain, in which up to two nonadjacent methylene units of said alkylidino are optionally and independently replaced by -CO-, -CS-, -COCO-, -CONR2-, -CONR2NR2- -CO2-, -OCO-, -NR2CO2-, -O-, -NR2CONR2-, -OCONR2-, -NR2NR2-, -NR2NR2CO-, -NR2CO-, -S-, -SO-, -SO2- , -NR2-, -SO2NR2-, NR2SO2- or -NR2SO2NR2-； Q is a bond or is a C1-C6 alkyldino chain eal or branched, in which up to two adjacent methylene units of Q are optionally and independently replaced by -O-, -S- or in which up to a methylene unit of Q are replaced by NH or N (C1-C4 alkyl) RQ is phenyl, quinoline or indolen which RQ is optionally substituted with up to 4 substituents selected from R1, R2, R3, R4 and R5, each of RN and RM is independently R2；Un compuesto de fórmula I:**Fórmula**o una sal farmacéuticamente aceptable del mismo；en la que:el anillo Z es, en la que Z está opcionalmente sustituido con hasta z apariciones de Rz；z es 0 a 4；cada Rz se selecciona independientemente entre R1, R2, R3, R4 y R5；el grupo SO2 se une a cualquiera de los carbonos nº 1 ó 2；el grupo NRM-C(O)-Q-RQ se une a cualquiera de los carbonos nº 3' o 4'；en la que el anillo fenilo que contiene el carbono nº 3' está opcionalmente sustituido con hasta 4sustituyentes seleccionados entre halo, CN, NO2 CF3, OCF3, OR6, SR6, S(O)R2, SO2R2, NH2, N(R2)2,COOR2 y una cadena alquilidino C1-C6 lineal o ramificada, en la que hasta dos unidades metileno noadyacente
