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Substituted piperidines as soluble epdxide hydrolase inhibitors
专利权人:
The Regents of the University of California
发明人:
Bruce D. Hammock,Kin Sing Lee,Bora Inceoglu,Karen Wagner
申请号:
US14375704
公开号:
US09850207B2
申请日:
2013.02.01
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Provided are methods for treating, reducing, alleviating, and/or inhibiting neuropathic pain by orally, intravenously or intrathecally administering an effective amount of an inhibitor of soluble epoxide hydrolase (“sEH”), to a patient in need thereof. The neuropathic pain treated is selected from the group consisting of post-herpetic neuralgia, trigeminal neuralgia, focal peripheral nerve injury, and anesthesia dolorosa, central pain due to stroke or mass lesion, spinal cord injury, or multiple sclerosis, and peripheral neuropathy due to diabetes, HIV, or chemotherapy.
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