composições farmaucêuticas e veterinárias nas formas micro e nanoestruturadas e que formam micro e nanoestruturas no trato gastrointestinal contendo benznidazol e seus derivados e suas aplicações biológicas
Pharmaceutical and veterinary compositions in micro and nanoestruturadas forms and form micro and nanostructures in the gastrointestinal tract with benznidazole and its derivatives and their biological applications the present invention describes methods for preparation of pharmaceutical forms polim\u00e9 Rich micro and nanom\u00e9tricas encapsulating benznidazole for parenteral use and dosage forms for oral use QThe EU autoemulsionam in contact with biological fluids, forming micro - or nanoemuls\u00f5es. Include microcapsules, microspheres, microemulsions, nanoc\u00e1psulas, nanocesferas, nanoemuls\u00f5es, solid lipid nanoparticles, semi - solid and liquid, nanoc\u00e1psulas lipid core and systems autoemulsion\u00e1veis, forming micro and nanoemuls\u00f5es.The formulations to be patented include pharmaceutical forms which have structure of emulsified cells coated or not with polymers containing benznidazole and \/ or a derivative nitroimidaz\u00f3licos.The pharmaceutical compositions developed improve the dissolution profile of benznidazole, control the release of the drug and promote increase of plasma bioavailability, thus improvement of pharmacological activity.composições farmacêuticas e veterinárias nas formas micro e nanoestruturadas e que formam micro e nanoestruturas no trato gastrointestinal contendo benznidazol e seus derivados e suas aplicações biológicas a presente invenção descreve os métodos de preparo de formas farmacêuticas poliméricas micro e nanométricas encapsulando o benznidazol para uso parenteral e de formas farmacêuticas de uso oral que se autoemulsionam em contato com fluidos biológicos, formando micro ou nanoemulsões. incluem microcápsulas, microesferas, microemulsões, nanocápsulas, nanocesferas, nanoemulsões, nanopartículas lipídicas sólidas, semi-solidas e líquidas, nanocápsulas de núcleo lipídico e sistemas autoemulsionáveis, que formam micro e nanoemulsões. as formulações a serem patenteadas incluem formas farmacêuticas que possuem es
