Harald Rau,Susanne Kindermann,Torben Lebmann,Grethe Norskov Rasmussen,Ulrich Hersel,Thomas Wegge,Kennett Sprogoe
申请号：
US15000242
公开号：
US10098930B2
申请日:
2016.01.19
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A chemically modified human Growth Hormone (rhGH) prepared by attaching a transient linker which comprises a polyethylene glycol. The chemically modified protein may have a much longer lasting rhGH activity than that of the unmodified rhGH, enabling reduced dose and scheduling opportunities and the modified rhGH may not cause lipoatrophy. Also includes methods of use for the treatment and/or prevention of diseases or disorders in which use of growth hormone is beneficial.
