Shelley Lynn Scoville,Amanda F. Taylor,Steven Charlebois,Christine M. Steinhart,Neal E. Fearnot
申请号：
US15058329
公开号：
US09993580B2
申请日:
2016.03.02
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Osteogenic compositions include a decellularized extracellular matrix tissue and bone morphogenic protein, preferably BMP-2. The compositions make beneficial use of the BMP, which can be used at relatively low doses and can bind to native components (e.g., native sulfated glycosaminoglycans such as heparin and/or heparan sulfate) remaining in the decellularized extracellular matrix tissue. Methods for preparation and use of such compositions are also described. The compositions and related methods can be used in the treatment of diseased or damaged bone tissue.
