A medical rubber closure (1) according to the present invention includes a disc-shaped flange portion (2) and a leg portion (4) formed to be continuous to a lower surface side (3) of the flange portion (2), and a region at the lower surface side of the flange portion and the leg portion are made of a nitrile based rubber, a region at a top surface side of the flange portion is made of a butyl based rubber, and the leg portion is laminated with a coating layer (13) made of a fluorine based resin film.
