Human monoclonal antibodies against protein tyrosine kinase 7 (PTK7) and their use

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专利权人:

メダレックス エル.エル.シー.;メダレックス;エル．エル．シー．

发明人:

ルー， リ－シェン,テレット， ジョナサン アレクサンダー,パン， チン,ルー, リ-シェン,テレット, ジョナサン アレクサンダー,パン, チン

申请号：

JP2008544528

公开号：

JP5401639B2

申请日:

2006.12.08

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/