A nozzle cap (1) to be attached to a nozzle of a medical prefilled syringe is provided. The nozzle cap (1) includes a nozzle cap body, and a film (8) provided at least on an inner surface of the nozzle cap body. The film (8) has a liquid contact portion (6) to be possibly brought into contact with a liquid drug contained in the syringe, and a retention portion (7) to be brought into contact with an outer periphery of the nozzle. The liquid contact portion (6) of the film (8) has a greater thickness than the retention portion (7) of the film (8). The nozzle cap (1) for the prefilled syringe is excellent in sealability, and less liable to adversely influence a liquid drug contained in the syringe. A medical prefilled syringe is also provided, which employs the nozzle cap.