WEITZMAN AARON,MUELLER THOMAS,AFTAB DANA T,HOLLAND JAYMES
申请号：
NZ62464310
公开号：
NZ624643A
申请日:
2010.08.06
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is a process for preparing N-(4-{ [6,7-bis(methyloxy)quinolin-4-yl]oxy} phenyl)-N&rsquo-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide including preparation of 4&ndash(6,7&ndashDimethoxy&ndashquinoline&ndash4&ndashyloxy)&ndashphenylamine from 4-Aminophenol and 4-chloro-6,7-dimethoxyquinoline and further reacting 4&ndash(6,7&ndashDimethoxy&ndashquinoline&ndash4&ndashyloxy)&ndashphenylamine with 1&ndash(4&ndashfluoro&ndashphenylcarbamoyl)&ndashcyclopropanecarbonyl chloride.
