Johan Lub;Marc Stefan Robillard;Raffaella Rossin;Dirk Burdinski;Pascal Renart Verkerk
发明人:
Marc Stefan Robillard,Raffaella Rossin,Johan Lub,Pascal Renart Verkerk,Dirk Burdinski
申请号：
US13264425
公开号：
US20120034161A1
申请日:
2010.04.12
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other a cyclooctene or cyclooctyne.
