Systems and methods for administering spinal cord stimulation (SCS) based on temporal patterns of electrical stimulation are disclosed. According to an aspect, a method includes using a computational model of a wide-dynamic range (WDR) neuron to determine one or more non-regular temporal patterns that results in predetermined WDR neuronal output and stimulation activity for one of efficacy optimization and efficiency optimization. The method also includes administering to a subject spinal cord stimulation based on the determined one or more of the non-regular temporal patterns.
