A highly safe biological adhesive sheet capable of exerting a strong adhesive force almost without requiring a pressing force when the biological adhesive sheet is attached to living tissue. The biological adhesive sheet includes a substrate in which a plurality of through-holes are formed and an adhesive section in which a plurality of protrusions that protrude on one surface side of the substrate are formed, wherein the protrusions make contact with living tissue and are made to adhere to the living tissue by a Van der Waals forces by drawing the living tissue from the other surface side of the substrate through the through-holes.
