I discloses a method of treating cancer and a pharmaceutical composition with a CD44 antagonist. Glioma, colon cancer, breast cancer, prostate cancer, ovarian cancer, lung cancer, renal cell carcinoma, gastric cancer, esophageal cancer, head cancer, neck cancer, pharmaceutical compositions and methods of these, or pancreatic cancer, in certain aspects and a step of treatment with the CD44 fusion protein, a mammal having a cancer, such as melanoma. It is possible CD44 fusion proteins and these include CD44-Fc fusion protein, is used to detect the hyaluronic acid. None [Selection Figure]CD44拮抗薬を用いた医薬組成物及び癌の治療方法を開示する。特定の側面においてこれらの医薬組成物及び方法は、神経膠腫、結腸癌、乳癌、前立腺癌、卵巣癌、肺癌、腎細胞癌、胃癌、食道癌、頭部癌、頸部癌、膵癌、又は黒色腫などの癌を有する哺乳動物を、CD44融合タンパク質を用いて治療する工程を含む。これらCD44融合タンパク質はCD44-Fc融合タンパク質を含み、かつ、ヒアルロン酸の検出に用いることができる。【選択図】なし
