An activating mechanism (20) for activating an endoscopic ligator is disclosed. The activating mechanism (20) includes a mounting component (21) and an activating component (22) coupled thereto. The mounting component (21) inserts directly into the proximal opening of an operating channel of an endoscope and is dimensioned to fit within the operating channel to mount the mechanism (20) to the endoscope. The mounting component (21) includes a channel receiving an activation line of the ligating device which is threaded through the operating channel and the channel in the mounting component, and onto the activating component (22) of the activating mechanism (20). The activation line attaches to a spool (50) of the activating component (22). The activating component (22) further provides a drive pin (40) and a roller clutch (70) for setting the activating component (22) in an engaged or a disengaged position and a knob (60) for rotating the drive pin (40). When the drive pin (40) is engaged with the roller clutch (70), the knob (60) can only rotate in one direction. When the drive pin (40) is in the disengaged position from the roller clutch (70), the knob (60) can rotate in either direction.
