Bulli Padmaja Tadi;Hector F. DeLuca;Margaret Clagett-Dame;Lori A. Plum
发明人:
Hector F. DeLuca,Bulli Padmaja Tadi,Lori A. Plum,Margaret Clagett-Dame
申请号：
US12171045
公开号：
US08222236B2
申请日:
2008.07.10
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This invention discloses 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs, and specifically 2-methylene-(20E)-20(22)-dehydro-19-nor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefore. This compound exhibits relatively high transcription activity as well as pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also shows lower activity in vivo on bone calcium mobilization and similar in vivo intestinal calcium transport activity compared to the native hormone 1α,25-dihydroxyvitamin D3, and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
