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UTILISATION D'UNE HOLOTOXINE POUR RÉDUIRE LA DÉGRADATION ASSOCIÉE AU RÉTICULUM ENDOPLASMIQUE DE PROTÉINES MAL PLIÉES
专利权人:
THE HOSPITAL FOR SICK CHILDREN
发明人:
LINGWOOD, CLIFFORD
申请号:
EP10811085
公开号:
EP2470192A4
申请日:
2010.08.27
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
Provided is a use of a holotoxin to reduce endoplasmic reticulum-associated degradation (ERAD) of misfolded or abnormally folded proteins The holotoxin can thus be used in a method to treat diseases related to ERAD Examples of misfolded proteins that are degraded in the ER include the cystic fibrosis transmembrane conductance regulator (CFTR) delta F508 mutant protein, a misfolded mutant (G268V) of multi-drug resistance 1 (MDR1), and the glucocerebrosidase (GCC) enzyme in Gaucher's disease cells Examples of suitable holotoxins include ricin, shiga toxin, exotoxin A, plasmid-encoded toxin, cholera toxin, and verotoxin 1 (VT1) VT1 is also known as verotoxin A, shiga-like toxin 1, shiga-like toxin 1, or shiga toxin in type 1 A non-toxic inactive VT1 can also be used wherein crucial residues of the A subunit active site are mutated, for example, the mutations Y77S and E167Q
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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