The Brigham and Women's Hospital, Inc.;Massachusetts Institute of Technology
发明人:
申请号：
EP18801958.2
公开号：
EP3624888A1
申请日:
2018.05.17
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).De manière générale, cette invention concerne des composants à charge relativement élevée de principes pharmaceutiques actifs (p. ex., médicaments). Dans certains modes de réalisation, le composant (p. ex., composant d'interface tissulaire) comprend un agent thérapeutique solide (p. ex., API solide) et un matériau de support (p. ex., liant polymère) de façon que l'agent thérapeutique solide soit présent dans le composant en une quantité supérieur
