Xiaoqi Chen,Kang Dai,Jason Duquette,Michael W. Gribble, Jr.,Justin N. Huard,Kathleen S. Keegan,Zhihong Li,Sarah E. Lively,Lawrence R. McGee,Mark L. Ragains,Xianghong Wang,Margaret F. Weidner,Jian Zhan
申请号:
US13425817
公开号:
US08623885B2
申请日:
2012.03.21
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure:where R1 is a group of Formula IA, Formula IB, Formula IC, or Formula IDand the definitions of the other variables are provided herein.