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一種新的3-氮雜雙環[3‧1‧0]己烷衍生物以及其醫藥用途
专利权人:
SANWA KAGAKU KENKYUSHO CO. LTD
发明人:
TANIKO Kaori,MIYAZAWA Toshiyuki,KANEKO Tatsuroh,KURUMAZUKA Daisuke,HARADA Satoko,IZUCHI Toru,OKABE Morio,IWAMURA, Ryo,TSUZAKI, Yasunori,SETOGUCHI, Hiroyuki,IMURA, Yuuki,AKAZA, Hiroto,SHIMIZU, Motohisa,谷古香,宮澤俊行,金子達朗,車塚大輔,原田聰子,井土徹,岡部守男,岩村亮,津崎康則,瀨戶
申请号:
HK16109076.0
公开号:
HK1220973A
申请日:
2016.07.29
申请国别(地区):
HK
年份:
2017
代理人:
摘要:
The object of the present invention is to provide a compound having an antagonistic action against µ-opioid receptors, which causes less side effects and thus is highly safe. A compound represented by the general formula (I), or a pharmacologically acceptable salt thereof: wherein R 1 and R 2 are the same or different, and each represents a hydrogen atom or a halogen atom, provided that R 1 and R 2 are not simultaneously halogen atoms, R 3 represents a C 1 -C 3 alkyl group or a vinyl group, and R 4 represents the formula (II): wherein R 5 represents a hydroxy group or a C 1 -C 3 alkoxy group, and R 6 and R 7 are the same or different, and each represents a hydrogen atom or a halogen atom; or the formula (III): wherein Ring A represents a halogen atom(s)-substituted C 5 -C 7 cycloalkyl group which is optionally substituted by a C 1 -C 3 alkoxy group, or a halogen atom(s)-substituted 5- to 7-membered saturated heterocyclic group.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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