Vega Masignani,Michele Anne Barocchi,Monica Moschioni,Paolo Ruggiero
申请号：
US13375759
公开号：
US20120076814A1
申请日:
2010.06.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Pneumococcal pilus subunit RrgB has at least three clades. Serum raised against a given clade is active against pneumococci which express that RrgB clade, but is not active against strains which express one of the other two clades i.e. there is intra-clade cross-protection, but not inter-clade cross-protection. Thus an immunogenic composition can include at least two different clades of RrgB to improve strain coverage against pilus-containing pneumococci. These multiple clades may be present in the immunogenic composition as separate polypeptides or may be fused as a single polypeptide chain.
