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NOUVEAU DÉRIVÉ D'ACIDE -PHÉNOXYBENZÈNEACÉTIQUE ET PRÉPARATION PHARMACEUTIQUE LE CONTENANT
专利权人:
Kowa Company; Ltd.
发明人:
申请号:
EP10780296.9
公开号:
EP2436675A1
申请日:
2010.05.28
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
An α-phenoxybenzeneacetic acid derivative represented by general formula (I), which has both an angiotensin II receptor antagonistic activity and a PPARγ activation activity and is useful as a prophylactic and/or therapeutic agent for hypertension, metabolic syndrome or the like, a salt of the derivative, or a solvate of the derivative or the salt; and a pharmaceutical composition containing the derivative, the salt or the solvate. [In the formula, Q represents a group represented by formula (II) or (III) [wherein R1 and R1' independently represent a C1-6 alkyl group; R2 and. R2' independently represent a substituted or unsubstituted C1-6 alkyl group; R3 represents a hydrogen atom, a substituted or unsubstituted C1-6 alkyl group, or a group represented by formula (IV) [wherein X and Y independently represent CH or N; Z represents a C1-6 alkylene chain, or the like; R11 represents a hydrogen atom, a C6-10 aryl group, or the like; and m represents 0 or 1] ; and R4 represents a substituted C1-6 alkyl group]; R5 and R6 independently represent a C1-6 alkyl group: R7 represents a carboxyl group, or the like; R8, R9 and R10 independently represent a hydrogen atom, a halogen atom, or the like; and n represents an integer of 1 to 3.]
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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