METHODS FOR REDUCING THE EMERGENCY FREQUENCY OF A RESISTANT TREATMENT HEPATITIS C VIRAL INFECTION TO DELAY THE EMERGENCY OF A TREATMENT RESISTANT HEPATITIS C VIRAL INFECTION TO REDUCE THE RESISTANCE LEVEL OF A VIRAL TREATMENT INFECTION TO REDUCE THE EMERGENCY OF AN HCV-796 RESISTANT HEPATITIS C VIRAL INFECTION, TO IDENTIFY AN INDIVIDUAL WITH A REDUCED PROBABILITY TO ANTI-HEPATITIS DIAGNOSTIC OR DIAGNOSTIC DIAGNOSIS MONITORING TREATMENT IN A PATIENT TO MONITOR THE TREATMENT COURSE OF HEPATITIS C VIRAL INFECTION IN A PATIENT TO PROGNOSTIC DEVELOPMENT OF A HEPATITIS C VIRAL INFECTION RESISTANT TO
The present invention provides methods of decreasing the frequency of emergence, decreasing the level of resistance, and delaying the emergence of a treatment-resistant Hepatitis C viral infection, by administering to a subject, either in combination or in series, an inhibitor of the Hepatitis C RNA-dependent RNA polymerase NS5B, e.g., a benzofuran, such as 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide (HCV-796), and at least one additional anti-Hepatitis C agent, e.g., a ribavirin product or an immunomodulator, such as an interferon product. Additionally, the invention relates to methods of monitoring the course of treatment of a Hepatitis C viral infection, methods of monitoring and prognosing a Hepatitis C viral infection, and methods of identifying an individual with a decreased likelihood of responding to an anti-Hepatitis C viral therapy. These methods use the sequence and/or structure of the Hepatitis C RNA-dependent RNA polymerase NS5B to identify the emergence of a treatment-resistant Hepatitis C viral infection, particularly a benzofuran (e.g., HCV-796) treatment-resistant Hepatitis C viral infection.
