There is provided a method for oral drug dosage medicament regime adherence monitoring comprising creating an oral drug dosage medicament regime for a patient, the medicament regime having a plurality of medicament intervals for the oral consumption of a plurality of oral drugs, loading the plurality of oral drugs into a cartridge of an oral drug dispensing device, providing a patient wearable vital sign monitoring device for being worn by the patient and associating the patient wearable vital sign monitoring device and the oral drug dispensing device with a patient profile, the patient profile being further associated with the oral drug dosage medicament regime. Then, for at least one medicament interval, the method comprises: alerting the patient of the medicament interval using at least one of the patient wearable vital sign monitoring device and the oral drug dispensing device； obtaining first vital sign measurement data for the patient using the patient wearable vital sign monitoring device； detecting the dispensing of an oral drug from the cartridge of the of oral drug dispensing device； obtaining second vital sign measurement data for the patient post the dispensing using the patient wearable vital sign monitoring device, and comparing the first and second vital sign measurement data to calculate a probability of the oral consumption of the oral drug.
