The present invention relates to imidazole derivatives of the general formulawherein R1 signifies halogen, lower alkyl or lower alkoxy； R2 signifies lower alkyl, lower hydroxyalkyl or lower alkoxyalkyl； R3 signifies hydrogen, lower alkyl, lower hydroxyalkyl or alkoxyalkyl； Q signifies either-N= or -CH=； R4 is a group of formula IIa or IIbwherein X, Y and Z independently are -CH= or -N=, and whereby only one of X or Y can be a nitrogen atom； R5and R6independently are hydrogen, lower alkyl, lower hydroxyalkyl, lower alkoxyalkyl, -(CH2)m-(CO)O-lower alkyl, -(CH2)m-S(O)2-lower alkyl, -(CH2)m-C(O)-NR'R" and where m=0-3 and R'and R"are independently hydrogen or lower alkyl； as well as to pharmaceutically acceptable salts thereof.It has now surprisingly been found that the compounds of general formula I are metabotropic glutamate receptor antagonists. They can be used in the treatment or prevention of mGluR5 receptor mediated disorders.本發明係關於一種以下通式之咪唑衍生物及其醫藥上可接受的鹽，其中R1 表示鹵素、低碳數烷基或低碳數烷氧基；R2 表示低碳數烷基、低碳數羥烷基或低碳數烷氧基烷基；R3 表示氫、低碳數烷基、低碳數羥烷基或烷氧基烷基；Q 表示或-N=或-CH=；R4 表示式IIa或IIb之基團其中X、Y及Z係獨立地為-CH=或-N=，且因此X或Y中僅一個可係氮原子；R5與R6係獨立地為氫、低碳數烷基、低碳數羥烷基或低碳數烷氧基烷基、-(CH2)m-(CO)O-低碳數烷基、-(CH2)m-S(O)2-低碳數烷基、-(CH2)m-C(O)-NR'R"且其中m=0至3且R'及R"係獨立地為氫或低碳數烷基。現已驚訝地發現通式I化合物係代謝型榖胺酸受體拮抗劑。其等可用於治療或預防由mGluR5受體介導的疾病。
