HOF ROBERT PATRICK,KRIEK MARIA ALDEGONDA JACOBA,SCHAAPER WILHELMUS MARTINUS MARIA,SCHENKELAARS EVERARDUS JOANNES PETER MARIA,TURKSTRA JOUWERT ANNE,VAN BREE JOHANNES GERNARDUS MATHIAS MARIE
申请号：
NZ70851511
公开号：
NZ708515A
申请日:
2011.06.03
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is the use of a trisaccharide derivate comprising a substituted trisaccharide core, which trisaccharide core is fully substituted with fatty acid ester groups, and optionally one or more anionic groups in the preparation of a medicament for use as an adjuvant. The substituted trisaccharide core may be derived from raffinose, melezitose, maltotriose, nigerotriose, maltotriulose or kestose and may comprise one or two sulphate ester or phosphate ester groups. The fatty acid ester may be the ester of lauric acid, myristic acid, palmitic acid, stearic acid or arachidic acid. The disclosure also relates to a kit comprising the derivative. Further disclosed is an adjuvant composition comprising: a. a substituted trisaccharide derivate as the adjuvant, wherein the core of the derivate is derived from raffinose, melezitose, or maltotriose and wherein the core is fully substituted with one sulphate ester or phosphate ester group and ten identical fatty acid ester groups or with two sulphate or phosphate ester groups and nine identical fatty acid ester groups and b. at least one of a pharmaceutical acceptable excipient and diluent.
