INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
DIMARCHI, RICHARD D.,SMILEY, DAVID L.,DIMARCHI, MARIA,CHABENNE, JOSEPH,DAY, JONATHAN,PATTERSON, JAMES,WARD, BRIAN C.
申请号：
CA2728284
公开号：
CA2728284C
申请日:
2009.06.16
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Modified glucagon peptides are disclosed having enhanced potency at theglucagon receptor relative to nativeglucagon. Further modification of the glucagon peptides by formingintramolecular bridges or the substitution of the terminalcarboxylic acid with an amide group produces peptides exhibiting glucagon/GLP-1 receptor co-agonist activity. The solubility andstability of these high potency glucagon analogs can be further improved bymodification of the polypeptides by pegylation,acylation, alkylation, substitution of carboxy terminal amino acids, C-terminal truncation, or the addition of a carboxy terminal peptideselected from the group consisting of SEQ ID NO: 26 (GPSSGAPPPS), SEQ ID NO:27 (KRNRNNIA) and SEQ ID NO: 28(KRNR).
