Cellules souches hématopoïétiques traitées par fucosylation in vitro et procédés d'utilisation

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专利权人:

OKLAHOMA MEDICAL RESEARCH FOUNDATION

发明人:

申请号：

EP10181456.4

公开号：

EP2327760B1

申请日:

2004.03.03

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

A method of in vitro fucosylation of selectin ligands on cord blood-derived hematopoietic stem cells for bone marrow transplantation is disclosed. In this method, an effective amount of an ±1,3-fucosyltransferase, e.g., ±1,3-fucosyltransferase VI, is used in vitro to treat cord blood-derived hematopoietic stem cells to convert non-functional PSGL-1 or other ligans on the cell surface into functional forms that bind selectins, especially P-selectin or E-selectin. The treated cells have enhanced effectiveness in reconstituting bone marrow in patients in need of such therapy.

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