Capsule for oral administration comprising n Tert Butyl [(3 - 5 - methyl - 2 - ((4 - (2) - pyrrolidin-3-yl - 1 - iletoxi) phenyl] amino} pyrimidin-4-yl) amino] benzenesulfonamide, microcrystalline Cellulose and sodium Stearyl fumarate； Unit dosage form； method to treat myelofibrosis； method of Preparation On； and article Preparation.

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专利权人:

TARGEGEN; INC.

发明人:

JAYAN, ARVIND,CACACE, JANICE,TEFFERI, AYALEW

申请号：

CL2013001252

公开号：

CL2013001252A1

申请日:

2013.05.06

申请国别(地区):

CL

年份:

2014

代理人:

摘要：

Provided herein are compositions and methods for treating myelofibrosis in a subject. The methods comprise administering to the subject an effective amount of compound which is which is N-tert-butyl-3-[(5-methyl-2-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide or a pharmaceutical salt thereof or a hydrate thereof.FORMULACIÓN ORAL QUE COMPRENDE DICLORHIDRATO DE N-TERC-BUTIL-3-[(5-METIL-2-{[4-(2-PIRROLIDIN-1-ILETOXI)FENIL]AMINO}PIRIMIDIN-4-IL)AMINO]BENCENOSULFONAMIDA MONOHIDRATO, UNA CELULOSA MICROCRISTALINA Y ESTEARIL FUMARATO DE SODIO； MÉTODO PARA SU PREPARACIÓN； Y SU USO PARA TRATAR MIELOFIBROSIS.

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http://www.ckcest.cn/home/