John Knopf;Ravindra Kumar;Robert S. Pearsall;Kristian Pietras;Asya Grinberg;Jasbir Seehra
发明人:
Asya Grinberg,John Knopf,Ravindra Kumar,Robert S. Pearsall,Jasbir Seehra,Kristian Pietras
申请号：
US12434598
公开号：
US08158584B2
申请日:
2009.05.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALK1 may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction.
