PREPARATION FOR PLURIPOTENT VERY SMALL EMBRYONIC/EPIBLAST-LIKE STEM CELLS (VSELS) AND HEMATOPOIETIC STEM/PROGENITOR CELLS (HSPC) CD34+ MOBILISATION FROM BONE MARROW TO PERIPHERAL BLOOD AND THE USE OF METFORMIN (N,N-DIMETHYLBIGUANIDE)
The object of the present invention is a preparation for pluripotent very small embryonic/epiblast-like stem cells (VSELs) and hematopoietic stem/progenitor cells (HSPC) CD34+ mobilisation from bone marrow to peripheral blood, characterised in that it contains metformin, and the usage of metformin for pluripotent very small embryonic/epiblast-like stem cells (VSEL) and hematopoietic stem/progenitor cells (HSPC) CD34+ mobilisation from bone marrow to peripheral blood and for use in treatment or prevention of conditions associated with reduced regenerative potential or premature senescence of cells.
