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Compounds and methods of use
- 专利权人:
- Xi, Ning;Sunshine Lake Pharma Co., Ltd.
- 发明人:
- Xi, Ning
- 申请号:
- ES12182915
- 公开号:
- ES2599458T3
- 申请日:
- 2009.10.09
- 申请国别(地区):
- ES
- 年份:
- 2017
- 代理人:
- 摘要:
- A compound of Formula (I): ** Formula ** or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a pharmaceutically acceptable salt thereof, in which: Q1 is of formula (IIa) or (IIb): ** Formula ** Q2 is of formula (III): ** Formula ** R1 is selected from: ** Formula ** in which each of X4 and X4 'is independently ( CR4R4a) m, NR5, O, S, S>; = O or SO2; each of m and n is independently 0, 1 or 2; and t is 1, 2 or 3; R2 is H, halo, cyano (CN), R5aR5N-C1-6 alkoxy, C1-6 alkoxy, C1-6 hydroxyalkoxy, C1-6 aminoalkoxy, C1-6 hydroxy substituted aminoalkoxy, C1-6 haloalkoxy, C1-6 alkylamino -C1-6 alkoxy, C1-6 alkoxy-C1-6 alkoxy, C4-10 heterocyclyloxy-C1-6 alkoxy, C5-12 bicyclyl condensate, C5-12 bicyclyl C1-6 aliphatic condensate, C5-12 aliphatic condensate heterocyclyl C1- 6, C5-12 condensed bicycloxy, C5-12 condensed bicyclylamino, C5-12 condensed bicycloxy-C1-6 alkoxy, C5-12 bicyclylamin condensed-C1-6 alkoxy, C5-12 condensed C-12 cyclyl (>; = O) -, C5-12 bicyclyl condensate-C (-O) O, heterobicyclyl C5-12 condensate-C (>; = O) -, heterobicyclyl C5-12 condensate-C (>; = O) O-, bicyclylamin C5-12 condensate- C ( >; = O) -, C5-12 heterobicyclocyl-condensate-C (>; = O) -, C5-12 bicyclyl condensate-C (>; = O) NR5-, C5-12 heterobicyclyl-condensed-C (>; = O) NR5-, spiro-bicyclyl C5-12, spiro-bicycloxy C5-12, spiro-bicyclylamino C5-12, spiro-bicycloxy C5-12- alkoxy C1-6, spiro-bicyclylamin C5-12-alkoxy C1-6, heterobicyclyl C5-1 2 condensate, heteroxycycloxy C5-12 condensate, heterobicycloxylamino C5-12 condensate, heterobicycloxy C5-12 condensate-alkoxy C1-6, heterobiciclilamin-C5-12 condensate-alkoxy C1-6, spiro-bicyclic C5-12, spiro-heterobicyclyl C5- 12, spiro-bicyclyl C5-12 aliphatic C1-6, spiroheterobicyclyl C5-12 aliphatic C1-6, spiro-heterobicycloxy C5-12-alkoxy C1-6, spiro-heterobiciclilamin C5-12-alkoxy C1-6, spiro-bicyclyl C5 -12-C (>; = O) -, spiro-bicyclyl C5-12-C (>; = O) O-, spiro-heterobicyclyl C5-12-C (>; = O) -,
- 来源网站:
- 中国工程科技知识中心
- 来源网址:
- http://www.ckcest.cn/home/