Compounds and methods of use

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专利权人:

Xi, Ning;Sunshine Lake Pharma Co., Ltd.

发明人:

Xi, Ning

申请号：

ES12182915

公开号：

ES2599458T3

申请日:

2009.10.09

申请国别(地区):

ES

年份:

2017

代理人:

摘要：

A compound of Formula (I): ** Formula ** or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a pharmaceutically acceptable salt thereof, in which: Q1 is of formula (IIa) or (IIb): ** Formula ** Q2 is of formula (III): ** Formula ** R1 is selected from: ** Formula ** in which each of X4 and X4 'is independently ( CR4R4a) m, NR5, O, S, S>； = O or SO2； each of m and n is independently 0, 1 or 2； and t is 1, 2 or 3； R2 is H, halo, cyano (CN), R5aR5N-C1-6 alkoxy, C1-6 alkoxy, C1-6 hydroxyalkoxy, C1-6 aminoalkoxy, C1-6 hydroxy substituted aminoalkoxy, C1-6 haloalkoxy, C1-6 alkylamino -C1-6 alkoxy, C1-6 alkoxy-C1-6 alkoxy, C4-10 heterocyclyloxy-C1-6 alkoxy, C5-12 bicyclyl condensate, C5-12 bicyclyl C1-6 aliphatic condensate, C5-12 aliphatic condensate heterocyclyl C1- 6, C5-12 condensed bicycloxy, C5-12 condensed bicyclylamino, C5-12 condensed bicycloxy-C1-6 alkoxy, C5-12 bicyclylamin condensed-C1-6 alkoxy, C5-12 condensed C-12 cyclyl (>； = O) -, C5-12 bicyclyl condensate-C (-O) O, heterobicyclyl C5-12 condensate-C (>； = O) -, heterobicyclyl C5-12 condensate-C (>； = O) O-, bicyclylamin C5-12 condensate- C ( >； = O) -, C5-12 heterobicyclocyl-condensate-C (>； = O) -, C5-12 bicyclyl condensate-C (>； = O) NR5-, C5-12 heterobicyclyl-condensed-C (>； = O) NR5-, spiro-bicyclyl C5-12, spiro-bicycloxy C5-12, spiro-bicyclylamino C5-12, spiro-bicycloxy C5-12- alkoxy C1-6, spiro-bicyclylamin C5-12-alkoxy C1-6, heterobicyclyl C5-1 2 condensate, heteroxycycloxy C5-12 condensate, heterobicycloxylamino C5-12 condensate, heterobicycloxy C5-12 condensate-alkoxy C1-6, heterobiciclilamin-C5-12 condensate-alkoxy C1-6, spiro-bicyclic C5-12, spiro-heterobicyclyl C5- 12, spiro-bicyclyl C5-12 aliphatic C1-6, spiroheterobicyclyl C5-12 aliphatic C1-6, spiro-heterobicycloxy C5-12-alkoxy C1-6, spiro-heterobiciclilamin C5-12-alkoxy C1-6, spiro-bicyclyl C5 -12-C (>； = O) -, spiro-bicyclyl C5-12-C (>； = O) O-, spiro-heterobicyclyl C5-12-C (>； = O) -,

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