Certain embodiments are directed to a biofluid flow assist device comprising (a) a collar configured to wrap at least partially around a subject's neck or limb； (b) at least one biofluid flow assist mechanism configured to be position over a target when the collar is positioned on the subject's neck or limb； and (c) a controller operatively connected to the biofluid flow assist mechanism. In certain aspects the biofluid is blood, lymph, and/or cerebrospinal fluid (CSF).
