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SUSTAINED RELEASE DOSAGE FORM FOR LUBRICATING AN ORAL CAVITY
专利权人:
BENNES; INC.
发明人:
GIN, JERRY, B.,ROSS, BENJAMIN, F.
申请号:
EP08833820
公开号:
EP2242484A4
申请日:
2008.09.26
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
Aspects of the invention include a sustained release dosage form that can be administered to an oral cavity, e.g., the mouth. In certain embodiments, the sustained release dosage form is formulated as a lozenge or gum that may be administered to an oral cavity for the purpose of providing lubrication therein. In certain embodiments, the sustained release dosage form not only provides lubrication to a mucosal surface of an oral cavity, but also provides for the sustained release of a flavoring and/or beneficial agent. Accordingly, in certain embodiments, the sustained release dosage form includes a water-insoluble polymer, e.g., ethylcellulose, an essential oil component, and an effective amount of a film forming binder, e.g., xanthan gum. In certain embodiments, the effective amount of the film forming binder and the type of film forming binder are selected so as to provide the sustained release dosage with the capability of lubricating one or more mucosal surfaces within an oral cavity when the dosage form is positioned therein. In certain embodiments, the sustained release dosage form is formulated in a manner sufficient to form a matrix that includes the various components of the sustained release dosage form, such that when positioned in an oral cavity the matrix slowly dissolves and thereby lubricates the oral cavity and/or delivers a flavoring and/or beneficial agent thereto. Methods of formulating such dosage forms and administering them to an oral cavity for the treatment of an adverse condition are also provided.Linvention concerne dans certains aspects une forme posologique pouvant être administrée dans une cavité orale, par exemple la bouche. Dans certains modes de réalisation, la forme posologique à libération prolongée est formulée comme une tablette ou gomme pouvant être administrée dans une cavité orale pour lubrifier celle-ci. Dans certains modes de réalisation, la forme posologique à libération prolongée permet non seulement la lubrification dune su
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来源网址:
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