Kellen L. Olszewski,Ji-In Kim,Masha V. Poyurovsky,Kevin G. Liu,Anthony Barsotti,Koi Morris
申请号：
US16397043
公开号：
US20190315772A1
申请日:
2019.04.29
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided hererin are compounds that modulate glucose uptake activityand are useful for treating cancer, autoimmune diseases, inflammation, infectious diseases, and metabolic diseases. In certain embodiments, the compounds modulate glucose uptake activity by modulating cellular components, including, but not limited to those related to glycolysis and the known transporters/co-transporters of glucose such as GLUT1 and other GLUT family members/alternative hexose transporters. In certain embodiments, the compounds have the structure of formula I:wherein the variables have the values disclosed herein.
